.Net Framework gets new updates and the vSphere client stops working. VMWare has this issue addressed on http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1022611
But they have not mentioned which updates should be removed if you cant update the vsphere client to "update 1" or "update 2".
This is the error that you get.


Remove the KB9980773 and KB976765 updates from control panel.


Now try connecting to vCenter server, if it fails, try restarting your system.
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